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The goal of the current study is to develop and validate a "mobile" protocol to train research assistants to verify the presence of common cold and influenza episodes, referred to as upper respiratory infections (URI).  This protocol, based upon techniques used by medical doctors and nurse practitioners to diagnose URIs, will be such that research assistants can use it in participants' homes.  An objective set of verification procedures for non-medical professionals does not exist in the field, and we think this would be a valuable tool for two reasons.  First, because individuals may report symptoms of an URI without a physiological basis, objectively verified URIs offer a cleaner assessment of actual illness than self-report.  Further, previous research in our lab suggests that when participants are asked to go to a medical professional to have their self-reported URIs verified, the majority of self-reported URIs (65% and 90%, respectively) go without a verification attempt.  We suspect that full schedules, wanting to remain in bed, and beliefs that "there was nothing medical staff could do because it just had to run its course" served as deterrents for participants to pursue verification.  TO achieve the aforementioned goals, investigators will work closely with our consultant (Director of Carnegie Mellon University (CMU) Student Health Center) to develop a URI verification manual and examination checklist.  Research assistants trained by us will then use these materials to guide their URI verification examinations on 90 CMU students presenting mild to severe respiratory symptoms.  To validate this protocol, we will also have these same 90 participants examined by a nurse practitioner and we will compare the research assistants' conclusions to nurses' diagnoses.  To evaluate its validity, we will then calculate our procedure's sensitivity (ability to correctly confirm URI), specificity (ability to correctly confirm the absence of URI), and efficiency (overall percentage of correct classifications).
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  12/7/2005  tc

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