Assistant Professor of Medicine Division of General Internal Medicine University of Pittsburgh School of Medicine Email: tindleha@upmc.edu Phone: 412-246-6929 Fax: 412-692-4838

Research Program
Dr. Tindle’s broad aim is to understand the neurobiology of human self-regulation through the
specific study of recovery from nicotine dependence.  She actively incorporates this knowledge
from her research into the care of patients who desire to change their behavior in positive ways.
Working closely with mentors in Psychology and the Center for the Neural Basis of Cognition,
Psychiatry, and Cardiology, Dr. Tindle is seeking answers to the following research questions:
1. What human brain systems subserve successful coping with cigarette craving?
2. What is the role of behavioral and pharmacologic therapy in successful coping?
Does tobacco cessation therapy a) alter the neurophysiology of craving, b) facilitate the
neurophysiology of coping or c) both.
3. Who can be taught to self-regulate, and what are the characteristics of individuals who
are likely to respond to therapy?